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HEPHAISTOS Pharma

ONCO-Boost, the first product from HEPHAISTOS-Pharma’s platform, is a natural TLR4 agonist that stimulates the patients’ own immune system to strengthen both innate and adaptive immune systems to strengthen their responses against cold tumors.

xista team

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Ingrid Kelly
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Next generation of immunostimulants against cancer

HEPHAISTOS-Pharma is a preclinical biotech company developing the next generation of immunostimulants against cancer, revolutionizing immune stimulation targeting TLR4 with a unique technology for intravenous administration, opening the way to metastatic and hard-to-treat indications.

HEPHAISTOS-Pharma is the laureate of prestigious grants such as BPIFRANCE i-Nov. In 2023, HEPHAISTOS was awarded a 2.5M€ EIC accelerator grant in Europe and is also part of the SyStInn consortium headed by academic partners that received a 9M€ RHU grant from the French National Research Agency, which will part-fund clinical trials on ONCO-Boost. HEPHAISTOS-Pharma is also one of the few innovative companies to be selected for its disruptive potential and supported by the Paris Saclay Cancer Cluster.

The HEPHAISTOS-Pharma Team

HEPHAISTOS-Pharma is headquartered in France, with a subsidiary in Liège, Belgium. The company was founded by Dr. Martine CAROFF, Alexey Novikov, and Frederic Caroff, who serves as the CEO. 

Our Investment Rationale

HEPHAISTOS has an impressive set of preclinical data, showing the high potential of their TLR4 agonist ONCO-Boost to tackle solid tumors, particularly in combination with immunotherapies such as checkpoint inhibitors.

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Investment process

1. Share your Information

Use the form to tell us about your startup. Our team will review the details provided and will get back to you as soon as possible. If you meet the required criteria, we’ll plan together the next steps of your funding journey.

2. Start the financing process

We start by inviting you to a meeting and gather more information relevant to conducting a due diligence process, evaluating your business plans, growth strategy, and financial forecasts. Together, we analyze and determine the essential details and deal structure to meet your unique financing requirements.

3. Raise capital

If we invest, we will likely lead your funding round and will help you to fill your round and guide you through the process. From round preparations to execution, our team is here to support you, ensuring a smooth and successful experience.

4. Go beyond financing

We will be your partner in everything you encounter while executing your plans. We offer continuous support and guidance as we firmly believe long-term succes is a shared mission.